Which cholinergic agents primarily target nicotinic receptors?

Cholinergic agents that primarily target nicotinic receptors include substances that directly stimulate these receptors in the nervous system. Nicotine, for instance, is a well-known agonist of nicotinic receptors located in both the central nervous system and at the neuromuscular junction. It is known for its ability to enhance neurotransmission by mimicking the effects of acetylcholine at these receptor sites.

Succinylcholine, on the other hand, acts as a depolarizing neuromuscular blocker. It binds to nicotinic receptors at the neuromuscular junction, leading to an initial stimulation of muscle contraction followed by paralysis. This mechanism helps to facilitate surgical procedures by inducing temporary paralysis, making it useful in anesthesia.

The combination of nicotine and succinylcholine underscores the specific targeting of nicotinic receptors, linking both compounds to their effects on muscle and neuronal activity through this receptor type. This focus on nicotinic receptor activity distinctly characterizes the agents in this choice, setting them apart from other cholinergic agents that may primarily affect muscarinic receptors or have different mechanisms of action.