T/F: Irreversible AChE inhibitors are used clinically.

Irreversible acetylcholinesterase (AChE) inhibitors are indeed not commonly used in clinical settings primarily due to their potential for severe side effects and toxicity. These agents result in a long-lasting increase in acetylcholine levels, leading to prolonged stimulation of cholinergic receptors. This can cause symptoms such as muscle paralysis, respiratory failure, and even death if not managed properly.

While certain irreversible AChE inhibitors may have been explored for treatment in specific conditions or in research contexts, they lack clinical approval for standard therapeutic use due to their safety profiles and the risk of cholinergic crisis. Therefore, stating that they are used clinically is incorrect, supporting the assertion that the answer is false. The clinical utility of these compounds is vastly overshadowed by their dangers, limiting their application primarily to research settings or specific scenarios where their use can be meticulously controlled and monitored.